tag:blogger.com,1999:blog-6007972849469702622.post3803882782820726584..comments2023-10-26T11:06:45.662-04:00Comments on The Cellular Scale: If you give a mouse a placebo...TheCellularScalehttp://www.blogger.com/profile/18379669883853001278noreply@blogger.comBlogger2125tag:blogger.com,1999:blog-6007972849469702622.post-85357899037013472832012-02-28T17:06:58.914-05:002012-02-28T17:06:58.914-05:00Great question, Andrea. The saline condition was i...Great question, Andrea. The saline condition was indeed after the mouse had been habituated to expect cocaine (from that specific lever) So these saline mice are 'expecting' real cocaine just as much as the mice that get the ineffectual cocaine. That shows that the modified cocaine is much more powerful than just the context and the expectation.TheCellularScalehttps://www.blogger.com/profile/18379669883853001278noreply@blogger.comtag:blogger.com,1999:blog-6007972849469702622.post-33321622385251927262012-02-28T16:21:22.360-05:002012-02-28T16:21:22.360-05:00This is a potentially really powerful model! I wa...This is a potentially really powerful model! I was curious: for the saline controls, is that after the mouse has been habituated to think that pressing that particular lever will give it cocaine, and now that lever is intead giving saline? Or is this a lever that has always given saline, or a new lever that gives saline? In short, I'm wondering whether there could be the same glutamate spike if the mouse pressed a lever that had always given cocaine, and now it suddenly switched to saline (it thinks it has initiated a reward response, and the glutamate spike represents that expectation), or if some aspect of the "placebo" response depends on it being cocaine that's released, even if it's cocaine that can't cross the B/B barrier.Andreahttps://www.blogger.com/profile/05092678076218626642noreply@blogger.com